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Comparative Gastroenterology

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IMAGE A IMAGE B

 

BACKGROUND

A 13 lb (6 kg), 9 year old, castrated male American Domestic Shorthair cat presents to your clinic with a 3 to 4 month history intermittent vomiting and weight loss. The owner tells you that the cat has had “hairball-associated” vomiting for the past year, but during the past 3 to 4 months has been losing weight and is not eating and drinking very well. Also, the vomiting has been "projectile", during the past month. The RDVM gave a 10 day course of metoclopramide, which seemed to help, but now is not working. The cat has been known to chew plastic and vomited a plastic foreign body recently. On presentation the cat is lethargic but responsive to external stimuli, checks out food but doesn’t eat, and vomits while being examined. The cat’s has a heart rate of 160 bpm, rectal temperature of 99°F, and respiratory rate of 28 breaths/min. Abdominal sounds are normal over the stomach and the cat “hunches-up” when it’s abdomen is being palpated. Ultrasonographic examination of the abdomen shows diffuse increase echogenicity of the liver and prominent muscularis layer of the small intestines with normal thickness of intestinal walls. You perform endoscopy of the esophagus, stomach and duodenum and you see the above image (image A, see above) in duodenal lumen. You remove the object via endoscopy using a snare and are left with image B (see above).

What’s your diagnosis?

What other diagnostic tests would be helpful in determining the diagnosis?

What treatment(s) would be appropriate?

 

DIAGNOSIS

The endoscopic image (A) revealed a blue plastic foreign body that was removed successfully with a snare inserted through the biopsy instrument. However, once the object was removed the endoscope was reintroduced and a duodenal stricture was diagnosed. Impression smears of biopsies taken from duodenal mucosa adjacent to the stricture revealed suppurative inflammation with mixed bacteria including large number of Clostridium spp. The epithelial cells appeared uniform and were not thought to be malignant. Further diagnostic tests in this cat included an exploratory celiotomy which showed 5 large multifocal strictures involving approximately 75% of the small intestine. A biopsy taken at surgery showed transmural proliferation lymphocytes with round basophilic nuclei and scant to no cytoplasm. The final diagnosis in this cat was obstruction secondary to intestinal lymphosarcoma. Stricture formation was probably the reason for the foreign body obstruction and further work-up and surgery revealed underlying neoplasia. The cat was euthanatized at surgery due to significant (75%) involvement of the small intestine and poor prognosis for recovery.

 

Authors:
Dr. Amy L. Holford
Dr. Frank M. Andrews
Dr. Linden E. Craig

 
Figure 1: Low magnification view of intestinal cross section
showing transmural proliferation of lymphocytes.
Figure 2: High magnification view of
the monomorphic population of lymphocytes.