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Comparative Gastroenterology

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BACKGROUND

A 4 year old intact liver and white male English Setter presents to your clinic right after the News Year’s holiday with a 3-month history of straining to defecate and recently frank blood in the feces. The RDVM put the dog on a stool softner and antibiotics about 3 weeks ago and the owner noted that the dog feces were more “runny” but still contained blood. The owner notes that the dog eats well and is active, but has lost some weight over the past 3 weeks. The dog is being fed Purina® maintenance dog food at manufacturers recommended levels. You put the dog on the examination table and he urinates all over you and the table. You quickly grab a urine dip-stix to test the urine and collect some in a tube as it runs off the table. The results show a specific gravity of 1.034, protein 1+, bilirubin 1+, and a pH of 7.5. You rush some to the lab and it shows 4+ bacteria and a few epithelial cells. You change your clothes and return to the examination room and complete your physical examination. The rectal temperature is 102.1°F, heart rate is 120 b/m, and respiratory rate is 20 breaths/m. Abdominal sounds are within normal limits and the dog has evidence of dried blood and diarrhea around the rectum. You score the dog’s body condition to be 2/5, according to the canine body condition scale you found on the internet at CatHelp-Online.com. You proceed to a digital rectal examination and it reveals decreased lumen size approximately 1-2 inches cranial to the rectum. The CBC showed a normal WBC (12,900/µl), but eosinophilia (1,806/µl) and chemistry panel results were unremarkable. You perform endoscopy of the rectum and colon and see the above images.

Authors:

  • Frank M. Andrews, DVM, MS, DACVIM
  • Linden Craig, VMD, PhD, DACVP

     
  • What about the U/A findings?

  • What’s your diagnosis?

  • What other diagnostic tests would be helpful in determining the diagnosis?

  • What treatment(s) would be appropriate?

 

DIAGNOSIS

The endoscopic view of the rectum and colon shows marked thickening and was nodular in nature. The colonic mucosa showed multifocal areas of ulceration. The ileo-colic junction appeared within normal limits. Biopsies of the rectum and colon near the stricture showed ulceration and eosinophilic inflammation in the lamina propria and submucosa (Figure 1A, low power; Figure 1B, high power). There were no apparent organisms seen on H&E stain, but Silver stain showed irregularly shaped, branching septate hyphae, suggestive of Pithium sp (Figure 2). Diagnosis: Pythiosis of the colon and rectum. The dog was discharged with oral antibiotics (Cephalexin, 500 mg, po, Q12h) to prevent secondary bacterial infection from rectal biopsies and continued on the stool softner (Lactulose). The owner was given the option to treat with itraconazole (10 mg/kg, po, Q24h) and the surgery service was consulted for resection of the stricture. The owner is contemplating the options!

 

 

Figure 1A: Biopsy of the distal colon showing ulceration of the mucosa and inflammation of the lamina propria and submucosa (H&E stained)

 

Figure 1B: Biopsy of the distal colon (higher power from Figure 1A) showing eosinophilic infiltration of the submucosa (H&E stain).

 

Figure 2: Biopsy of the distal colon stained with Silver Stain showing irregularly shaped, branching septate hyphae, suggestive of Pithium sp. (Cultures confirmed Pithium sp.)

 

DISCUSSION

  • What are the viable options in this case?

  • What is the prognosis with or without treatment?

  • Would surgery help?

  • Please discuss thoughts or experiences regarding this case or others like it on the CGS listserve.