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The University of Tennessee

The College of Veterinary Medicine

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Hussein Abdulhadi Nasser Al-Wadei, DVM, PhD

Dr. Al-Wadei
Research Assistant Professor
Department of Pathobiology
The University of Tennessee
2407 River Drive
Knoxville, TN 37996
Phone: (865) 974-5876
FAX: (865) 974-5616

Education

  • 2004, PhD in Comparative and Experimental Medicine, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
  • 1992, DVM in Veterinary Medicine and Animal Resources, College of Veterinary Medicine and Animal Resources, King Faisal University, Saudi Arabia.

Professional Experience

  • October 2009, Research Assistant Professor, Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville
  • December 2007, Assistant Professor, Sana’a University, Sana’a, Yemen
  • June 2006, Research Associate I, Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville
  • December 2004, Post-Doctoral Research Associate, Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville
  • January 2002, Graduate Student Assistant, Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville
  • August 1994, Teaching Assistant, Department of Animal Production, College of Agriculture, Sana’a University, Sana’a, Yemen
  • 1992-2000, Technical advisor for several public and private sections of small animals, large animals, poultry farms and hatcheries all over the north part of Yemen

Courses Taught

  • 1994-2000, I taught the following courses at the Department of Animal production, College of Agriculture, Sana’a University, Sana’a, Yemen
    • Basic of Animal production, and Animal health
    • Basic of Veterinary Science
    • Milk and Meat Production and Hygiene
    • Poultry Diseases and Treatment
    • Animal Diseases and Treatment
    • Signs of Health and Disease in Animals and poultry

Research Interests

  • Research focuses on the development of novel strategies for the prevention and treatment of cancer in the lungs and pancreas. Lung cancer and pancreatic cancer are the leading causes of cancer mortality in the United States and all over the world because they fail to respond to existing cancer therapeutics and efforts to prevent these cancers by dietary measures or pharmacological treatments have failed

Grants

  • NIH, Challenge grant “Modulation of cancer prevention by social stress.”Project period: Two years starting September 2009. The goal of this project is to test the hypothesis that social stress decreases the effectiveness of cancer preventive agents in xenograft models for lung cancer and pancreatic cancer. Role in project: Co-investigator
  • NIH, RO1 “GABA-B-R- mediated prevention of pancreatic cancer.” Project period: 11-10-2009 until 10-31-2014. The goal of this project is to test the hypothesis that GABA-B-R agonists prevent pancreatic cancer. Role in project: Co-investigator
  • NIH, RO1“The GABA-B receptor is a novel drug target for pancreatic cancer.” Project period: 07-01-2009 until 04-30-2013. The goal of this project is to test the hypothesis that agonists for the GABA-B receptor are effective therapeutics for pancreatic cancer. Role in project: Co-investigator
  • National Lung Cancer Partnership “Estrogen enhances the carcinogenic effects of nicotine derivative NNK.” Project period: 01-01-08 through 12-31-2009. The goal of this project is to test the hypothesis that estrogen promotes the development of lung adenocarcinoma via synergistic cAMP-dependent signaling. Role in project: Co-investigator

Professional Societies

  • Active member- American Association for Cancer Research (AACR)
  • University of Tennessee National Alumni Association
  • Active member- Sana’a University Faculty Association
  • Yemen Veterinary Medicine Association

Recent Selected Publications

  • Hussein A. N. Al-Wadei, Mohammed H. Al-Wadei, Thomas Masi, and Hildegard M. Schuller. Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulate nicotinic receptors in small airway epithelial cells. [Lung cancer a head of print].
  • Hussein A. N. Al-Wadei, Mohammed H. Al-Wadei and Hildegard M. Schuller. Prevention of pancreatic cancer by the beta-blocker propranolol. Journal of “ Anti-Cancer Drugs.2009 July;20(6):477-82.
  • Hildegard M. Schuller and Hussein A. N. Al-Wadei. Beta-carotene-induced non-genomic signaling and cancer [Invited chapter].In: Haugen L,Bjornson T, eds.Beta-carotene: Dietary Sources, Cancer, and Cognition. Hauppauge, NY: Nova Publisher. In press.
  • Hussein A. N. Al-Wadei and Hildegard M. Schuller. Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas. Journal of Pathology. 2009 August; 218(4): 437-45.
  • Hussein A. N. Al-Wadei and Hildegard M. Schuller. ß-carotene promotes the development of NNK-induced small airway-derived lung adenocarcinoma. European Journal of Cancer. 2009 May; 45(7):1257-64.
  • Hussein A. N. Al-Wadei and Hildegard M. Schuller. Non-genomic inhibitory signaling of ß-carotene in squamous cell carcinoma of the lungs. International Journal of Oncology. 2009 April; 34(4): 1093-8.
  • Hussein A. N. Al-Wadei, Plummer HK III, Hildegard M. Schuller. Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid. Carcinogenesis. 2009 March; 30(3): 506-11.
  • Hildegard M. Schuller, Hussein A. N. Al-Wadei, Mourad Majidi. Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma. Carcinogenesis. 2008 Oct; 29(10):1979-85.
  • Hildegard M. Schuller, Hussein A. N. Al-Wadei, Mourad Majidi. GABA B receptor is a novel drug target for pancreatic cancer. Cancer. 2008 Feb 15; 112(4):767-78.
  • Mourad Majidi, Hussein A.N. Al-Wadei, Takashi Takahashi, and Hildegard M. Schuller. Non-genomic beta estrogen receptors enhance beta 1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Research. 2007 July15; 67(4):6863-71.
  • Maria Cekanova, Mourad Majidy, Thomas Masi, Hussein A. N. Al-Wadei, Hildegard M. Schuller. Overexpressed Raf-1 and phosphorylated cyclic adenosine 3 -5 -monophosphatate response element-binding protein are early markers for lung adenocarcinoma. Cancer. 2007 Mar 15; 109(6):1164-73.
  • Hussein A.N.Al-Wadei, Mourad Majidi, Ming-Sound Tsao, Hildegard M.Schuller. Low concentrations of Beta-carotene stimulate the proliferation of human pancreatic duct epithelial cells in a PKA-dependent manner. Cancer Genomics and Proteomics. 2007 Jan-Feb; 4(1):35-42.
  • Hussein A. N. Al-Wadei, Hildegard M. Schuller. Cyclic adenosine monophosphate-dependent cell type-specific modulation of cell proliferation by retinoids in normal and neoplastic lung cells. Cancer Detection and Prevention. 2006 Oct 25; 30(5): 403-11.
  • Hussein A. N. Al-Wadei, Takashi Takahashi, Hildegard M. Schuller. Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by ß-carotene via activation of cAMP, PKA, CREB, and ERK1/2. International Journal of Cancer. 2006 March 15;118(6):1370-80.
  • Hussein A. N. Al-Wadei, Takashi Takahashi, Hildegard M. Schuller. Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB, and ERK1/2. Oncology Reports. 2006 Feb;15(2):431-5.
  • Hussein A. N. Al-Wadei, Takashi Takahashi and Hildegard M. Schuller. PKA-dependant growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone. European Journal of Cancer. 2005 Nov.; 41(17):2745-53.
  • Hussein A. N. Al-Wadei, Takashi Takahashi, Hildegard M. Schuller. Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia. International Journal of Oncology. 2005 Jul; 27(1):155-60.
  • Hussein A. N. Al-Wadei. Premedication anesthesia for castration of a camel. Al-Faisal Medical Journal. 1992 Feb; 20(1):265-75.