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The University of Tennessee

The College of Veterinary Medicine

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Madhu S. Dhar, PhD


Research Assistant Professor
Department of Large Animal Clinical Sciences
College of Veterinary Medicine
The University of Tennessee
2407 River Drive
Knoxville, TN 37996-4500
Phone: (865) 974-5703
FAX: (865) 974-5773

Education

  • Ph.D. Chemistry, University of Poona, India
  • M.S. Biochemistry, University of Poona, India
  • B.S. Chemistry, University of Poona, India

Training

  • 1990 Postdoctoral fellow Biochemistry and Cellular Biology, Univ. of Tenn. Knoxville, TN
  • 1992 Postdoctoral fellow Graduate School of Biomedical Sciences, Univ. of Tenn. Knoxville, TN
  • 1998 Research Assistant Professor Oak Ridge National Laboratory, Oak Ridge, TN
  • 2004 Research Assistant Professor Large Animal Clinical Sciences, College of Veterinary Medicine, Knoxville, TN
  • 2006 Research Associate Professor Large Animal Clinical Sciences, College of Veterinary Medicine, Knoxville, TN

Teaching

  • Undergraduate and Graduate student research training
  • Graduate and postgraduate course: General, organic and biochemistry
  • Graduate course: Introduction to Genome SCI/TECI - Polygenic Mouse Models of Obesity
  • Graduate and postgraduate course: Evaluation of genetic and nutritional control of obesity and glucose homeostasis
  • Graduate course: Advanced Topics in Nutrition. Nutrient-Gene Interactions in Health and Disease
  • Undergraduate and graduate course: Plant genetic engineering : DNA cloning and sequencing

Research Interests

  • Animal models of human disease with special relevance to obesity and diabetes
  • Novel targets of Role of glucose transporters and amino phospholipid translocases in insulin resistance
  • Regulation of gene expression in mouse adipocytes in vivo and in vitro
  • Role of G-protein linked potassium channels in breast cancer cells
  • Glucose and Lipid Metabolism in lean and obese horses

Clinical Interests

  • Link basic molecular and cellular research to clinical cases
  • Identify molecular and cellular targets for complex diseases for translational research.
  • Regenerative medicine - adipose tissue as a source of adult stem cells.

Honors and Awards

  • 2009 Member, Editorial Board, The Open Obesity Journal.

  • 2008 Member, Region 2 Study Section, American Heart Association, Basic Cell and Molecular Biology (Mid-Atlantic and Greater Southeast) Apr 2008-2011.

  • 2007 Best Poster Award for "Tobacco carcinogens stimulate G-protein inwardly rectifying potassium channel 1 (GIRK1) protein expression in a small cell lung cancer cell line." Authored by Madhu S Dhar, Michael W. Hance and Howard K. Plummer III. Presented at the Ion Channel Targets Conference, Boston, MA. September 10-11, 2007.
  • 2007-2008 Chair, Large Animal Clinical Sciences, Research Committee
  • 2006 Nominated as the Honorary Member of UT Phi Zeta (Tennessee Chapter at University of Tennessee College of Veterinary Medicine)
  • 2006 First author of BMC Physiology paper which was cited as one of the 30 best publications by Lead Discovery, a company for pharmaceutical targeted research areas.
  • 2006-2007 Invited Member of the Working Committee of Genome India International.
  • 2006 Hot Topic Abstract "A type IV P-type ATPase affects insulin-mediated glucose uptake in adipose tissue and skeletal muscle in mice and may be involved in protein trafficking and sequestration" selected for presentation at the Keystone Symposia on Adipogenesis, Obesity and Inflammation, Vancouver, British Columbia, Jan 21-26, 2006.
  • 2005 Invited reviewer for the Journal Nutrition and Metabolism
  • 2004 Invited reviewer for the Journal Experimental Biology and Medicine
  • 2003 Outstanding Mentor Award from United States Department of Energy in recognition of dedication as a Mentor to undergraduate research at Oak Ridge National Laboratory
  • 2002 Outstanding Research Poster Award for "A Novel Polygenic Mouse Model of Obesity and Diabetes: Evaluation of Genetic and Nutritional Control of Obesity and Glucose Homeostasis" in the category of Complex Genetics and Disease Modifiers, at the 16th International Mouse Genome Conference, San Anonio, Texas, Nov 17-21, 2002.
  • 2001-2002 Travel Award from the International Mammalian Genome Society to attend the 15th and 16th International Mouse Genome Conferences, Edinburgh, Scotland, Oct. 21-24, 2001.
  • 2001 Interactive Poster Award for "A murine aminophospholipid translocase on chromosome 7 is associated with an obesity phenotype" at FASEB Summer Research Conference on Transport ATPases (From Genomics to Mechanism) at Snowmass Village, Snowmass, Colorado. July 14-19, 2001.
  • 2000 Travel Award from the Oak Ridge Associated Universities and the International Mammalian Genome Society to attend the 14th International Mouse Genome Conference, Narita, Japan, Nov. 6-9, 2000.

Research Support

Current
  • Pilot and Feasibility grant, University of Tennessee Obesity Research Center, Feb 1, 2009 - Jan 30, 2010. (PI)
  • Project Grant for "Characterization of a P-type ATPase in dog adipose tissue: a novel target for metabolic diseases in mammals" American Kennel Club, May 1, 2008 - Apr 30, 2009. (PI)
  • Center of Excellence, University of Tennessee, 2005 - present
  • Research, Large Animal Clinical Sciences, Univ. of Tennessee College of Veterinary Medicine 2004 - present.
Previous
  • Philip Morris External Research Program "GIRK channels, beta adrenergic signaling and breast cancer" (Co-PI), 07/2004 - 06/2007
  • Beginning Grant - in - Aid American Heart Association, Southeast "Glucose Metabolism in a novel mouse model of obesity associated with insulin resistance" (PI), 07/2004 - 07/2006
  • Small Animal Clinical Sciences, University of Tennessee "Genetic basis of melanoma in dogs" (Collaborator), 10/2005 - 01/2006
  • National Institute of Health "Mapping and Cloning of an Obesity locus on Mouse chromosome 7" (Co-PI), 04/1998 - 07/2004
  • Department of Energy "Development of a New X-Ray CT based Methodology for Mouse Obesity Studies" (Co-PI), 01/1999 - 01/2000

Professional Societies

  • To establish in vitro and in vivo systems to study the biology of novel targets for obesity and diabetes
  • To validate novel candidate genes in mice, humans and companion animals for their roles in obesity and diabetes
  • To establish siRNAs as therapeutic drugs against clinically important diseases.
  • To optimize the isolation and identification of stem cells from equine peripheral blood and adipose tissue.

Professional Societies

  • International Mammalian Genome Society
  • North American Association for the Study of Obesity
  • Tennessee Mouse Genome Consortium

Publications

Students

  • Tanisa Kirkland MS, Oak Ridge National Laboratory/University of Tennessee, 2003-2005
  • Jennifer Stafford, DVM University of Tennessee, College of Veterinary Medicine 2005
  • Lora Abbott DVM, University of Tennessee, College of Veterinary Medicine 2006 - 2007
  • Helen Reaves DVM, University of Tennessee, College of Veterinary Medicine 2006
  • Sara Roshwalb DVM, University of Tennessee, College of Veterinary Medicine 2008
  • Amanda Peretich MS, Comparative and Experimental Medicine Program, University of Tennessee, College of Veterinary Medicine 2006-2008
  • Michael Hance PhD, Comparative and Experimental Medicine Program, University of Tennessee, College of Veterinary Medicine 2006-present
  • Sarah Hurst MS, Comparative and Experimental Medicine Program, University of Tennessee, College of Veterinary Medicine 2008-present
  • Sarah Grogerman DVM, University of Tennessee, College of Veterinary Medicine 2009