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The University of Tennessee

The College of Veterinary Medicine

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Kellie Fecteau, Ph.D.


Clinical Assistant Professor
Department of Comparative Medicine
College of Veterinary Medicine
The University of Tennessee
2407 River Drive
Knoxville, TN 37996
VTH A205
Phone: (865) 974-
FAX: (865) 974-5640
Email
Reproduction Research Group

Present Position

Research Assistant Professor, Clinical Endocrinology Service Laboratory, Department of Comparative Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville

Education

  • BS Animal Science University of New Hampshire, Durham, 1990 MS Animal Science
  • Reproductive Physiology The University of Tennessee, Knoxville, 1994 Advisor: Hugo Eiler, DVM, Ph.D.
  • Thesis title: Interaction of oxytetracycline and bacterial collagenase in the treatment of bovine retained placenta Ph.D. Animal Science Reproductive Physiology The University of Tennessee, Knoxville 1999 Advisor: Hugo Eiler, DVM, Ph.D. Dissertation Title: The role of fetal serotonin (5-HT) in bovine placenta detachment

Training

  • 2002-2003 Postdoctoral Fellow in Reproductive Biology, Department of Comparative Medicine
  • College of Veterinary Medicine, The University of Tennessee, Knoxville
  • Primary Investigator: Charmi Mendis-Handagama, DVM, Ph.D
  • 1999-2002 Postdoctoral Fellow in Molecular Oncology, Department of Comparative Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville
    Primary Investigator: Hwa-Chain R. Wang, DVM, Ph.D.

Book Chapter

  • Eiler, H., and Fecteau, K.A. Retained Placenta. In Youngquist, R.S. (ed): Current Therapy in Large Animal Theriogenology, 2nd ed. Philadelphia: W.B. Saunders Company. Expected publication date: 2003.

Scientific

  • Haffner, J.C., Fecteau, K.A., and Eiler, H. (2003). Inhibition of Collagenase Breakdown of Equine Corneas by Tetanus Antitoxin, Equine Serum, and Acetylcysteine. Veterinary Ophthalmology. 6:67-72.
  • Fecteau, K.A., Mei, J, and Wang, H.C.R. (2002).Differential Modulation of Signaling Pathways and Apoptosis ofras-Transformed 10T1/2 Cells by the Depsipeptide FR901228. J.Pharmacol. Exp. Ther. 300:890-899.
  • Fecteau, K.A., and Eiler, H. (2001). Placenta Detachment: Unexpected High Concentrations of
    5-Hydroxytryptamine (Serotonin) in Fetal Blood and its Mitogenic Effect on Placental Cells in
    Bovine. Placenta. 22:103-110.
  • Wang, H.C.R., and Fecteau, K.A. (2000). Detection of a Novel Quiescence-Dependent Protein Kinase. J. Biol. Chem.275:25850-25857.
  • Fecteau, K.A., and Eiler, H. (1998). Evaluation of Inhibitory Effects of Doxorubicin on Collagenase Using a Bovine Placentome Model. In Vivo 12:485-488.
  • Fecteau, K.A., Haffner, J.C., and Eiler, H. (1998). The Potential of Collagenase as a New Therapy for Separation of Human Retained Placenta: Hydrolytic Potency on Human, Equine and Bovine Placentas. Placenta 19:379-383.
  • Haffner, J.C., Fecteau, K.A., Held, J.P. and Eiler, H.(1997). Equine Retained Placenta: Tolerance to Intraplacental Injections of Collagenase. Theriogenology 49:711-716.
  • Eiler, H., Wan, P.Y., Valk, N., and Fecteau, K.A.(1997). Prevention of Retained Placenta by Umbilical Injections of Collagenase in Cows Undergoing Cesarean Section: Tolerance Study. Theriogenology 48:1147-1152.
  • Eiler, H., Oliver, J.W., Andrews, F.M., Fecteau, K.A., Green, E.M., and McCracken, M. (1997). Results of a Combined Dexamethasone Suppression/Thyrotropin-Releasing Hormone Stimulation Test in Healthy Horses and Horses Suspected to Have a Pars Intermedia Pituitary Adenoma. Journal of the American Veterinary Medical Association 211, 1-3.
  • Fecteau, K.A. and Eiler, H. (1996). Evaluation of Injections of Collagenase and Oxytetracycline via the Umbilical Artery as Treatment for Retained Placenta in Cattle. American Journal of Veterinary Research 57, 522-525.

Scientific Abstracts

  • Fecteau, K.A., Eiler, H., and Mendis-Handagama, S.M.L.C.(2003). Molecular effects of melatonin and serotonin on the ERK signaling pathway in tumorigenic and non-tumorigenic human prostate epithelial cells. Proceedings of the American Association for Cancer Research 44:1280. American Association for Cancer Research 94th Annual Meeting, Toronto, Ontario, Canada.
  • Wang, H.C.R., Hu, H., Song, P., Mei, J., Fecteau, K.,Sun, Y., Tan, M. (2003). Activation and role of Krs1 in growth arrest of cells by anticancer agents. Proceedings of the American Association for Cancer Research 44:670. American Association for Cancer Research 94th Annual Meeting, Toronto, Ontario, Canada.
  • Fecteau, K.A., Mrkonjich, L., Lawrence, A., and Mendis-Handagama, S.M.L.C. (2003). Platelet-derived growth factor immunolocalization in postnatal rat testis interstitium. Journal of Andrology March/April Suppl.:81. American Society of Andrology 28th Annual Meeting, Phoenix, Arizona.
  • Fecteau, K.A., and Eiler, H. (2002). Fetal narcosis in bovine: relationship between blood serotonin concentration and sleep/wake states. Biology of Reproduction 66 (suppl. 1):328. The Society for the Study of Reproduction 35th annual Meeting, Baltimore, Maryland
  • Mei, J., Fecteau, K.A., and Wang, H.C.R. (2002). Transformation of noncancerous human breast epithelial MCF10A by the tobacco-specific carcinogen NNK. Proceedings of the American Association for Cancer Research 43:19. American Association for Cancer Research 93rd Annual Meeting, San Francisco, California.
  • Thomas, W., Fecteau, K.A., and Eiler, H. (2001). Control of fetal narcosis during pregnancy by serotonin in the bovine: electroencephalographic study. Biology of Reproduction 64 (suppl.1):597. The Society for the Study of Reproduction 34th Annual Meeting, Ottawa, Ontario.
  • Mendis-Handagama, S.M.L.C., Ariyaratne, H.B.S., Wang, H-C.R.,Fecteau, K.A., Mrkonjich, L. (2001). Effect of thyroidhormone on anti-mullerian hormone expression in the neonatal rattestis. Biology of Reproduction 64(Suppl. 1):254. The Society for the Study of Reproduction 34th Annual Meeting, Ottawa, Ontario.
  • Fecteau, K.A., and Wang, H-C.R (2001). Molecular effect of an anticancer agent FR901228 on signaling pathways in normal andras-transformed cells. Proceedings of the American Association for Cancer Research 42:208. American Association for Cancer Research 92nd Annual Meeting, New Orleans, Louisiana.
  • Eiler, H., and Fecteau, K.A. (2000). Mechanism of parturition: pivotal role of fetal serotonin in the regulation of placenta detachment, adrenal loop regulation, and fetal narcosis. Biology of Reproduction 62 (Suppl. 1):327. The Society for the Study of Reproduction 33rd Annual Meeting, Madison, Wisconsin.
  • Fecteau, K.A., and Eiler, H. (1999). Mechanism of parturition hypothesis: activation of fetal adrenal axis by fetal serotonin. Biology of Reproduction 60 (Suppl. 1):187. The Society for the Study of Reproduction 32nd Annual Meeting, Pullman, Washington.
  • Fecteau, K.A., and Eiler, H. (1999). Bovine isolated placentome model: testing alternative for the evaluation of antibiotics on matrix metalloproteinase activity. Gordon Research Conference: Non-antimicrobial properties of tetracyclines and other antibiotics. Proctor Academy, Andover, New Hampshire.

Patents

  • Provisional U.S. patent application filed (7-24-02) for Hugo Eiler and Kellie Fecteau by The University of Tennessee Research Corporation entitled "Method and Composition for Induction of Narcosis".

Ad hoc Reviewer

  • Placenta, 2002

Professional Societies

  • Society for the Study of Reproduction
  • American Association for Cancer Research
  • American Society of Andrology
  • Society for Comparative Endocrinology