T.W. Schultz, TW, MS, Ph.D.
Phone: (865) 974-5826
FAX: (865) 974-5640
B.S., Austin Peay State University
M.S., University of Arkansas
Ph.D., University of Tennessee
Post-Doctoral Investigator, Oak Ridge National Laboratory
Dr. Schultz coordinates The Biological-Activity Testing and Modeling Laboratory housed in the York Veterinary Teaching Hospital and has academic ties to the Department of Comparative Medicine, College of Veterinary Medicine and Department of Ecology and Evolutionary Biology, College of Arts and Sciences. Its mission also includes: the development, validation, and use of rapid and inexpensive assays for the evaluation of environmental toxicity; the development, validation, and use of structure-activity models for predicting toxic potency, and advancement of the basic understanding of toxicology, especially of industrial organic chemicals.
Current experimental systems being used include bacterial bioluminescent assays, protozoan population growth inhibition assay, yeast recombinant systems for endocrine disruption and toxicogenomics. Structure-toxicity modeling focuses on modeling across mechanisms of action and involves endpoints representing different trophic levels. Current model development involves knowledge-based expert systems for ecotoxicity and receptor-mediated endocrine modulation.
On going projects include studies of direct acting electrophiles, high production volume chemicals, and xenoestrogens and modeling no-observable-effects-concentrations. Other investigations are examining the bioactivities of polychlorinated biphenyls and polycyclic aromatic hydrocarbons, as well as thyroid modulators.
American Chemical Society
Society of Environmental Toxicology & Chemistry