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The University of Tennessee

The College of Veterinary Medicine

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Patricia K. Tithof, DVM, Ph.D.

Assistant Professor
Department of Pathobiology
College of Veterinary Medicine
The University of Tennessee
2407 River Drive
Knoxville, TN 37996
Phone: (865) 974-5819
FAX: (865) 974-5616


  • BS - University of Michigan, 1978
  • DVM - Michigan State University 1982
  • Internship, Large Animal Clinical Sciences, Univ. of Tennessee, 1983
  • Residency, Large Animal Surgery, Cornell University, 1983
  • PhD in Physiology, Michigan State University, 1993
  • Postdoctoral Training in Toxicology, 1996


  • Cardiovascular Physiology, Physiology of Blood, Mechanisms of Disease

Research Interests

My research interests include cardiovascular disease and atherosclerosis related to cigarette smoking and exposure to environmental air pollution. I am specifically interested in the mechanism by which components of cigarette smoke induce endothelial cell apoptosis.

Professional Societies

  • American Physiology Society
  • Phi Zeta-National Honor Society
  • Fellow-American Heart Association


  • Tithof PK, Contreras ML, Ganey PE. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Toxicology of Applied Pharmacology 131: 136-143.
  • Tithof PK, Peters-Golden M, Schiamberg E, Ganey PE. Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. Environmental Health Perspective104(1): 52-58.
  • Tithof PK, Ganey PE. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. Biochemistry and Pharmacology 53: 1833-1842.
  • Tithof PK, Peters-Golden M, Ganey PE. Distinct phospholipases A2regulate release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. Journal of Immunology 160: 953-960.
  • Schuller HM, Tithof PK, Williams M, Plummer H. The tobacco-specific carcinogen4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a ß-adrenergicagonist and stimulates DNA synthesis in lung adenocarcinoma via ß-adrenergic receptor-mediated release of arachidonic acid. Cancer Research 59: 4510-4515.
  • Olszewski MA, Robinson NE, Zhu FX, Zhang Y, Tithof PK, Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. American Journal of Physiology 276(3 Pt 1):L522-9.
  • Tithof PK, Olivero J, Ruehle K, Ganey PE. Activation of neutrophil calcium dependent-and–independent phospholipases A2 by organochlorine compounds. Toxicological Science 53:40-47.
  • Weddle DL, Tithof P, Williams M, Schuller HM. Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis 22(3): 473-479.
  • Tithof PK, Elgayyar M, Barnhill M, Schuller HM, Andrews R.4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells. Am. J.Physiol. 281:H1946-H1954
  • Schoieb AM, Dudrick PS, Bell JD, Tithof PK. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone.Int. J. Oncol. 22: 107-113, 2003.