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The University of Tennessee

The College of Veterinary Medicine

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Xuemin Xu, Ph.D.


Professor
Department of Pathobiology
College of Veterinary Medicine
The University of Tennessee
2407 River Drive
Knoxville, TN 37996
Phone: (865) 974-8206
FAX: (865) 974-5616
Email

Education

  • 1982 -- Department of Chemistry, Jilin University, Changchun (P.R. China) B.S. (Chemistry) awarded 3/82
  • 1985 -- Department of Life Science, Tokyo Institute of Technology, Nagatsuta, Yokohama 227 (Japan) M.S. (Biochemistry) awarded 3/85
  • 1989 -- Department of Life Science, Tokyo Institute of Technology, Nagatsuta, Yokohama 227 (Japan) Ph.D. (Molecular Biology) awarded 3/89
  • 1989 -- Graduate Fellow, Mitsubishi Kasei Corporation Research Center, Midori-ku Yokohama, 227 (Japan)
    Graduate Fellow
  • Fellowship: The Association for Overseas Technical Scholarship (AOTS) (4 April 1988 -- 31 March 1989)

Teaching

  • The graduate level core CEM course "Mechanisms of Disease"
  • 2000-present Adviser of PhD student: Essam Laag
  • 2002-present Adviser of PhD student: Guojun Zhao

Research Interests

  • The molecular and cellular mechanism of Alzheimer’s disease and related neurodegeneration.
  • The mechanism of apoptotic cell death found in Neurodegenerative Disease, specifically, Alzheimer’s disease.
  • Protein-protein interaction and its role in intracellular signal transduction.
  • I am currently conducting two research projects studying the pathological roles of
    1. presenilins
    2. apolipoprotein E in Alzheimer’s disease
    The goal of my research is to determine the normal functions of these genes in neuron development including differentiation and survival, and the pathological role of these genes in Alzheimer’s disease using molecular and cellular approaches.

Professional Services

  • Captive and free living wildlife medicine

Professional Societies

  • American Association for the Advancement of Science
  • Society for Neuroscience

Selected Recent Publications

  • Guozhang Mao, Yuanzhou Dong, Jianxin Tan, Mei-Zhen Cui, and Xuemin Xu (2008) Both the N-terminal fragment and the protein-protein interaction domain (pdz domain) are required for the pro-apoptotic activity of presenilin-associated protein PSAP, Biochimica et Biophysica Acta, 1780: 696-708.
  • Hao, F., Tan, M., S., Xu, X., Han, J., Miller, D., Tigyi, G., and Cui, M.-Z. (2007), Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38; Biochim Biophys Acta- Mol and Cell Bio Lipid, 1771: 883-892
  • Guojun Zhao, Jianxin Tan, Guozhang Mao, Mei-Zhen Cui, and Xuemin Xu (2007) The same γ-secretase accounts for the multiple intramembrane cleavages of APP. Journal of Neurochemistry, 100: p1234-1246.
  • Dong, Y., J. Tan, M.Z. Cui, G. Zhao, G. Mao, N. Singh, and Xu, X. (2006). Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation. Faseb J, 20(2): p. 331-3.
  • Cui, M.-Z., Laag, E., Zhao, G. and Xu, X., (2006) Immediate Early Gene Egr-1 Induction in Response to Lysophosphatidic Acid in Vascular Smooth Muscle Cells. Artherioscler, Thromb and Vasc Biol. 26: 1029-1035.
  • Guojun Zhao, Mei-Zhen Cui, Guozhang Mao, Jianxin Tan, Yunzhou Dong, Longsheng Sun, and Xuemin Xu (2005) γ-cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J. Biol. Chem., 2005. 280(45): p. 37689-37697.
  • Guojun Zhao, Mei-Zhen Cui, Guozhang Mao, Jianxin Tan, Yunzhou Dong, Seong-Hun Kim and Xuemin Xu (2004) Identification of a New Presenilin-dependent ζ-Cleavage Site within the Transmembrane Domain of Amyloid Precursor Protein. J. Biol. Chem., 2004. 279(49): p. 50647-50650. (Honored as Paper of the Week)
  • Tan, M., Xu, X., Ohba, M. and Cui, M.-Z., Protein kinase C delta mediates Angiotensin II-induced protein kinase D phosphorylation in aortic smooth muscle cells. (2004) Artherioscler, Thromb and Vasc Biol. 24: 2271-2276.
  • Mei-Zhen Cui and Xuemin Xu (invited commentary) Lysophosphatidic Acid, Tissue Factor and Atherosclerosis, 2003, at: http://www.athero.org
  • Cui, M.-Z. , Zhao, G., Winokur, A., Laag, E. Bydash J. R., Penn, M. S., Chisolm G. M., and Xu, X., (2003) Lysophosphatidic Acid Induction of Tissue Factor Expression in Aortic Smooth Muscle Cells. Artherioscler, Thromb Vasc Biol 23: 224-230.
  • Tan, M., Xu, X., Ohba, M., Ogawa W. and Cui, M.-Z. (2002), Thrombin rapidly induces protein kinase D phosphorylation and protein kinase C delta mediates the activation. J. Biol. Chem 278: 2824-2828.
  • Yaping Gu, Susamma Verghese, Ravi Mishra, Xuemin Xu, Yongchang Shi, and Neena Singh. (2002). Mutant prion protein (PrP) mediated aggregation of normal PrP in the endoplasmic reticulum: Implications for prion propagation and neurotoxicity. J of Neurochemistry 83: 1-13.
  • Xuemin Xu, Yong-chang Shi, Wei Gao, Guozhang Mao, Guojun Zhao, Sudesh Agrawal, Guy Chisolm, and Mei-Zhen Cui. (2002). The novel presenilin-1-associated protein (PSAP) is a pro-apoptotic mitochondrial protein. J Biol Chem 277: 48913-48922.