Oncology Clinical Trials at University of Tennessee Veterinary Medical Center
(Updated October 20, 2014 Knoxville, TN) -- The Oncology Service at the University of Tennessee Veterinary Medical Center (UTVMC) is currently conducting clinical trials recruiting the following tumor types (Please ask your veterinarian to contact our Oncology Service at (865) 974-8387 for more information or enrollment):
Updated October 2014
Dogs- histiocytic sarcoma (malignant histiocytosis), lymphoma, mast cell tumors, melanoma, multiple myeloma, osteosarcoma, squamous cell carcinoma (oral), soft tissue sarcoma, thyroid carcinoma, transitional cell carcinoma (bladder)
Cats- lymphoma, squamous cell carcinoma (oral)
NEW TUMOR TYPES!
1. NEW!! Tumor types: CANINE SOFT TISSUE SARCOMA AND LYMPHOMA.
Trial: Multi-center NCI-sponsored clinical trial evaluating novel indenoisoquinolone chemotherapy agents for canine lymphoma and soft tissue sarcomas
The goal of this trial is to a drug in tumor-bearing dogs. Dogs must have confirmed lymphoma or soft tissue sarcoma (bulky disease) to be eligible for the trial. This trial is fully funded and clients will receive a $1000 incentive at the end of the study period (29 days) to use for future therapy.
2. Tumor type: Canine T cell lymphoma (high grade)
Trial: Correlation of in vitro and in vivo responses to chemotherapy in canine lymphoma
In this study, we propose to correlate the data obtained from in vitro experiments with clinical response in your dog. The treatment offered is still standard of care. We will perform a fine needle aspirate of an enlarged lymph node to obtain cells for culture for this study in the same way as it is done for diagnostic purposes. We propose to test a variety of chemotherapy drugs in the cultured cells isolated from your dogs tumor. We will compare the clinical responses to chemotherapy with responses of cells in culture to same drug. We will preserve the extra tumor cells for future studies. These studies will help to develop the optimal (personalized) treatment. We believe that this is a valuable method for evaluation of new drugs for future clinical application. The study will cover the expenses for a CBC, chemistry/electrolytes, urinalysis, FNA (fine needle aspirate), immunophenotyping, chemotherapy drug and administration costs for dogs with T-Cell lymphoma during the initial visit, a recheck visit fee on day 7 will also be covered by the study (total cost of up to $500).
3. Tumor type: Canine B AND T cell lymphoma (high grade), OSTEOSARCOMA, and MULTIPLE MYELOMA
Trial: Evaluation of oncolytic viruses in canine cancer.
The goal of this trial is to evaluate the response of various tumor types to an oncolytic virus designed to infect cancer cells but not normal cells. This project is a collaboration with the Mayo clinic and funded by the Morris Animal Foundation (B cell lymphoma) and the UT Center of Excellence (T cell lymphoma, Osteosarcoma, Multiple Myeloma) evaluating a new and exciting approach to cancer treatment! This trial is fully funded but does require a 7-10 day hospitalization period depending on the tumor type. Tests required for eligibility determination: CBC, complete chemistry, urinalysis, thoracic radiographs. Patients ideally should be off other therapies (including steroids) for 2 weeks prior to enrollment. Trial period is for 30 days (~4 visits to UT).
4. NOW OPEN! Tumor Type: OSTEOSARCOMA
Trial: Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs with Osteosarcoma.
This study seeks to identify an optimal dose of the mTOR inhibitor, rapamycin, to be advanced to a canine clinical trial that will assess the role of rapamycin as an antimetastatic agent in dogs with osteosarcoma. An open label, prospective preclinical trial of orally administered rapamycin will be conducted in dogs with osteosarcoma. This is a fixed schedule, dose escalation study in dogs with measurable tumors. The primary objective of this study is to identify a tolerable chronic exposure of oral rapamycin in tumor-bearing dogs that is achievable in human patients and has been demonstrated to inhibit metastatic progression in murine models. Toxicity will be evaluated via dose escalation and assessment of dose limiting toxicities (DLT) and parallel assessment of pharmacokinetic exposures. The study is FULLY FUNDED and will provide rapamycin for dogs that respond for up to 6 months of treatment.
5. Tumor type: Feline oral squamous cell carcinomas.
Trial: Phase I trial of nanoencapsulated antisense CK2.
This trial aims to evaluate the tolerability of a novel gene therapy against CK2 in a targeted nanocapsule that homes specifically to cancer cells. Cats with oral squamous cell carcinoma confined to the oral cavity +/- regional lymph nodes may be eligible. The trial period is 3 weeks, with two treatments per week. Pre- and post-treatment biopsies are required to assess CK2 expression. The trial includes financial incentives, with drug supplied at no cost and cost of pre- and post-treatment biopsies and labwork is covered during treatment.
6. Tumor type: Feline high grade lymphoma.
Trial: Efficacy of High-dose L-asparaginase and Impact on Ammonia and Amino Acid Levels in Cats with High Grade Lymphoma.
The trial will evaluate the response of cats with lymphoma to a single treatment with L-asparaginase. The trial period is one week and includes three visits to UT for blood sampling and re-staging tests. This trial is funded and includes a free dose of Elspar and imaging studies. Patients need to be newly diagnosed within 7 days of enrollment and not on other therapy. After the study period ends, they may go on to receive other treatments.
7. Tumor type: Canine histiocytic sarcoma.
Trial: Phase II, Open Label Trial of Paccal Vet® (water-soluble micellar paclitaxel) in Dogs with Histiocytic Sarcoma.
The trial will evaluate a new canine chemotherapy agent, Paccal Vet, for canine histiocytic sarcoma. Paccal Vet has been studied in other canine tumors. This trial is funded. Trial period is a minimum of 6 weeks (3 required visits to UT), but additional Paccal Vet provided if dog responds to treatment. Patients need to be off other therapies (including steroids) for 2 weeks prior to enrollment.
8. Tumor type: Canine mast cell tumor.
Trial: Use of Kinavet (masitinib) for non-resectable canine mast cell tumors.
This is a double-blinded placebo-control trial that evaluates Kinavet in dogs with non-resectable mast cell tumors (2/3 of the dogs will receive Kinavet, 1/3 placebo). Dogs cannot be on chemotherapy and should be off steroids for at least 3 weeks. A screening visit to determine eligibility is required. The trial is fully funded.
9. Tumor Type: Canine thyroid carcinoma.
Trial: Evaluation of a novel hand held device to monitor response of canine thyroid carcinomas to radiation therapy. The trial period is 3 weeks. This trial includes a financial incentive of $500.
10. Tumor type: Canine transitional cell carcinoma.
Trial: Pilot study, Neurotransmitter levels in blood samples of dogs with and without transitional cell carcinoma.
Research by Dr. Schuller's lab has shown that high blood levels of cancer stimulating stress neurotransmitters can stimulate certain cancer types in vitro and in rodent animal models. The current pilot study will explore blood samples in dogs with transitional cell carcinoma to determine if they have increased stress neurotransmitter levels and/or decreased GABA levels. Patients must be untreated (NSAIDs are not allowed). Patients can present to UT or referring practitioners may submit blood for use in this study. A 5ml blood sample is needed for study- no cost to client for participation.
11. Tumor type: Canine Bladder transitional cell carcinoma
Trial: Evaluating a novel optical imaging agent, fluorocoxib A, to detect cyclooxygenase-2 (COX-2) expressing cancers of bladder in dogs. COX-2 enzyme is highly present in cancer cells, but not in normal cells that makes an attractive target for detection of cancer. This study using fluorocoxib A in dogs with naturally occurring cancers will assist to identify tumors that would benefit from COX-2 targeted NSAIDs. In addition, this study will assist to translate this novel imaging agent into clinical applications for detection of cancer, as well for monitoring the early responses to therapy not only in dogs, but also in human patients. This trial includes financial incentives to the client. Patients may be enrolled undiagnosed and the trial will pay for biopsy for diagnosis. Patients must be off NSAIDs for 2 weeks before enrollment or biopsy. Trial period is approximately 24 hours.
Please note: For all trials, patients must be examined at UTCVM to determine eligibility. Clients are often responsible for the initial examination fee for the first visit (currently $129) and any tests required by that trial to determine eligibility (many trials require some staging tests performed to determine eligibility but some may cover the cost of some tests). Each trial has different funding and an explanation of covered costs and non-covered costs will be reviewed with each case.
Posted: 05-19-14 Viewed: 21479 times
Media RelationsSandra Harbison
College of Veterinary Medicine
University of Tennessee
2407 River Drive
Knoxville, TN 37996